| Author (year) | 
        Patients | 
        AIT | 
        Allergen | 
        Study duration | 
        Parameter/ Results | 
       
      
        | Buchner (1995) (22) | 
        adults | 
        SCIT | 
        pollen, mites | 
        10 years | 
        - 54% costs for symptomatic treatment | 
       
      
        | Schadlich (2000) (27) | 
        adults | 
        SCIT | 
        pollen, mites | 
        10 years | 
        Saving/patient 650-1190 DM (€ 332-608) | 
       
      
        | Petersen (2005) (30) | 
        adults | 
        SCIT | 
        pollen | 
        4 years | 
        Saving/patient of 1508 DKK (€ 203) | 
       
      
        | Ariano (2006) (31) | 
         adults | 
        SCIT | 
        pollen | 
        6 years | 
        - 48% money spent at year 4 | 
       
      
        | Omnes (2007) (32) | 
        adults & children | 
        SCIT | 
        pollen, mites | 
        6 years | 
        saving/patient 1327 € for pollen allergy, 393 € for mites | 
       
      
        | Hankin (2008) (34) | 
        children | 
        SCIT | 
        pollen, mites | 
        1,5 years | 
        weighed    6-month saving/patient $ 401 (€ 308)  | 
       
      
        | Hankin (2010) (35) | 
        children | 
        SCIT | 
        pollen, mites | 
        1,5 years | 
        - 34% total healthcare cost/patient | 
       
      
        | Wang (2011) (36) | 
        adults | 
        SCIT | 
        pollen, mites | 
        1,5 years | 
        - 41% total healthcare cost/patient | 
       
      
        | Berto (2005) (37) | 
        children | 
        SLIT | 
        pollen, mites | 
        4 years | 
        Saving/patient 2043 €  | 
       
      
        | Berto (2006) (38)  | 
        adults | 
        SLIT | 
        pollen | 
        6 years | 
        Break-even at year 4 | 
       
      
        | Bachert (2007) (40) | 
        adults | 
        SLIT | 
        pollen | 
        9 years | 
        Cost-effective for SLIT cost <2200 €/year | 
       
      
        | Canonica (2007) (41) | 
        adults | 
        SLIT | 
        pollen | 
        4 years | 
        Cost-effective for SLIT cost <1900 €/year | 
       
      
        | Berto (2008) (39) | 
        adults | 
        SLIT | 
        pollen | 
        1 year | 
        - 34% costs for symptomatic treatment | 
       
      
        | Podladnikova (2008) (43) | 
        adults | 
        SLIT | 
        pollen | 
        3 years | 
        SLIT 684 € vs. SCIT 1004 € | 
       
      |