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| Figure 3: A synthetic circuit built by Kemmer et al. [57], that uses negative feedback to control the concentration of free urate. When no urate is present, the repressor mUTS efficiently suppresses the transcription of urate oxidase. When urate is present, it inhibits mUTS, allowing transcription of urate oxidase to proceed. The enzyme oxidizes (removes) urate. The system as a whole therefore works as a homeostat, keeping urate to low levels. |
