Sea urchin C. elegans Human Node N° of links Node N° of links Node N° of links [Ca2+]i 19 [Ca2+]i 10 [Ca2+]i 25 [H+]i 14 [H+]i 9 Tyr phosph. 13 ATP 9 ATP 7 ATP 15 cGMP 15 Motility 8 PKA 9 cAMP 13 Vesicle fusion 7         NADH 7         NAD+ 6         Pseudopod extension 6

Table 3: Most connected nodes (the hubs) of sea urchin, C.elegans and Human spermatozoa activation networks.

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