Original model which calibration set only containing crystalline form[17 ]
New model which calibration set containing amorphous and crystalline forms
Prediction content (%,mg/mg)
Content difference with true (HPLC 82.9%)
Prediction content (%,mg/mg)
Content difference with true (HPLC 82.9%)
0%
35.1
47.8
81.4
1.5
10%
40.7
42.2
79.7
3.2
20%
47.1
35.8
81.5
1.4
30%
51.6
31.4
82.0
0.9
40%
56.1
26.8
80.8
2.1
50%
60.9
22.0
81.5
1.4
60%
65.4
17.5
81.6
1.3
70%
69.9
13.0
82.3
0.6
80%
73.0
9.9
81.9
1.0
90%
77.3
5.6
82.6
0.3
100%
81.6
1.3
82.6
0.3
Mean (%)
59.9
23.0
81.6
1.3
RMSEP (%)
27.2
1.5
Table 8: The NIR Prediction results of ceftriaxone sodium with different crystallinity by models constructed from different calibration sets.
The results are shown in the Table 8. The PLS loading 1 of
