| Subject |
Kel
(1/hr) |
T1/2
(hr) |
C0
(μg/mL) |
AUClast
(hr×μg/mL) |
AUCINF_obs
(hr×μg/mL) |
AUC_
%Extrap_obs
(%) |
Vz_obs
(L/kg) |
Cl_obs
(mL/min/kg) |
MRTlast
(hr) |
| RAT-1 |
0.10 |
6.98 |
1770.47 |
1855.24 |
1946.55 |
4.69 |
1.36 |
2.25 |
3.39 |
| RAT-2 |
0.09 |
7.47 |
1606.31 |
1762.12 |
1858.79 |
5.20 |
1.52 |
2.35 |
3.39 |
| RAT-3 |
0.10 |
7.03 |
2065.39 |
2248.00 |
2361.61 |
4.81 |
1.13 |
1.85 |
3.50 |
| Mean |
0.10 |
7.16 |
1814.06 |
1955.12 |
2055.65 |
4.90 |
1.34 |
2.15 |
3.42 |
| SD |
0.00 |
0.27 |
232.62 |
257.88 |
268.58 |
0.27 |
0.20 |
0.26 |
0.06 |
| CV% |
3.69 |
3.77 |
12.82 |
13.19 |
13.07 |
5.44 |
14.83 |
12.28 |
1.82 |
|
