| Subject |
Kel(1/hr) |
T1/2(hr) |
Tma×(hr) |
Cma×
(μg/mL) |
AUClast
(hr×μg/mL) |
AUCINF_obs
(hr×ug/mL) |
AUC_%Extrap_obs
(%) |
Vz_F_obs
(L/kg) |
Cl_F_obs
(mL/min/kg) |
MRTlast
(hr) |
| RAT-1 |
0.69 |
1.01 |
0.50 |
28.04 |
40.77 |
44.42 |
8.22 |
8.60 |
98.49 |
1.33 |
| RAT-2 |
0.69 |
1.01 |
0.50 |
26.01 |
42.40 |
46.20 |
8.22 |
8.24 |
94.69 |
1.34 |
| RAT-3 |
0.77 |
0.90 |
0.50 |
24.99 |
49.12 |
52.18 |
5.88 |
6.51 |
83.84 |
1.42 |
| Mean |
0.72 |
0.97 |
0.50 |
26.35 |
44.10 |
47.60 |
7.44 |
7.78 |
92.34 |
1.36 |
| SD |
0.05 |
0.06 |
0.00 |
1.55 |
4.42 |
4.07 |
1.35 |
1.12 |
7.60 |
0.05 |
| CV% |
6.79 |
6.53 |
0.00 |
5.89 |
10.03 |
8.54 |
18.19 |
14.34 |
8.23 |
3.73 |
|
