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Figure 4: Cytotoxic activity of pSurvivin+95-104-specific cytotoxic T lymphocytes (CTLs). The CTLs were expanded by W6/32 antibody-mediated pSurvivin+95-104-specific aAPCs. The cytotoxic activity of one individual’s CTLs is shown. The cytotoxic activity of the CTLs was assessed against T2 cells pulsed without a peptide, T2pSurvivin+95-104 (the pSurvivin+95-104-pulsed T2 cells), T2pHIV (the pHIV-pulsed T2 cells), A172 (HLA-A2+-, Survivin++), U251 (HLA-A2++, Survivin++) and K562 at various effector:target (E:T) ratios. These results show that the cytotoxicity of the expanded CTLs is pSurvivin+95-104-specific. The bars in the graph represent standard error. |