- BDNF: Chemoattractive and promigratory via TrkBR [55,56], Promigratory via p75NTRs [50]
- PSA-NCAM: Disrupted migration in KO animals resulting in decreased OB size [57-59,64]
- β1 Integrins: Chemoattractive toward laminin via α6β1 [67], Decreased migration with anti-β1 integrin antibodies [38]
- Netrins: via DCC and neogenin receptors [38]
- Semaphorins: 3C and 3F attract axon growth via Neuropilin receptors in cortical and olfactory bulb tissues, respectively (reviewed in [80])
- MMPs: MMP2 and MMP9 enhance migration via PI3K/Akt and ERK1/2 [82], ADAM21 is present throughout the RMS and may be promigratory and chemoattractive [48]
- VEGF: Promigratory and chemoattractive with IQGAP1 as an effector molecule [83], Promigratory and chemoattractant via VEGFR2 and dependent on FGF2 [84,85]
- GDNF: Chemoattractive in the RMS via Cdk5 and dependent upon NCAM [86]
- HGF: Chemoattractant and Promigratory via the Met receptor and the Ras/MAPK pathway [87]
- ErbB4: Loss from neurons results in disrupted migration [88]
- Prokineticin 2: Chemoattractant via its G-protein coupled PKRs [90]
- Cannabinoids: via CB1 and CB2 receptors [91]
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Netrins: Repel from SVZ via DCCR [68], Repel axon growth via Unc 5-DCC complex receptor [69]
Slits: Chemorepellent from SVZ via RoboR [70,71] , dependent on astrocyte cues [72], Expressed in Septum, Choroid Plexus, and neuroblasts which lose chemorepellent activity in Slit KO animals [72]
Ephrins: Contact mediated EphB/EphrinB, [77]
Semaphorins: 3A, 3B, 3C, 3F repel axon growth via Neuropilin receptors in most neural tissuees (reviewed in [80], 3F repels migrating neuroblasts via Neuropilin 2 to confine them along normal migration paths [80]
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- GABA: Inhibits migration efficacy via GABAAR [53]
- Slits: [72,73]
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- PSA-NCAM: Disrupted chain formation without PSA [60,61]
- β1 Integrins: Disrupted chain formation in α6β1 KO animals [66]
- Ephrins: Inhibition disrupts chain formation [77]
- ErbB4: Loss from neurons results in disrupted chain organization [88]
- ROCK: Inhibition with Y27632 inhibits chain formation [89]
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- Reelin: [40,42]
- Tenascin-R: [41]
- Prokineticin 2: Chain dissociation cue at the OB via its G-protein coupled PKRs [90]
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