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| Figure 1: (a) Simplified illustration of episomal maintenance. S/MAR sequences (blue) mediate binding of chromosomal DNA (loops) to the nuclear scaffold (brown). pEPI is bound to the nuclear scaffold via a SAF A – S/MAR interaction. Presumably, additional proteins are involved. (b) FISH staining of pEPI molecules (purple) attached to metaphase chromosomes (blue), using the hitchhiking principle to be segregated during mitosis. |
