Experimental numbers T S Response (a.u) 1 -1 -1 8.64×108 2 1 -1 1.44×109 3 -1 1 1.06×109 4 1 1 1.64×109 5 1.414 0 1.82×109 6 -1.414 0 9.15×108 7 0 1.414 1.67×109 8 0 -1.414 1.11×109 9 0 0 1.27×109 10 0 0 1.24×109 11 0 0 1.38×109 12 0 0 1.53×109 13 0 0 1.28×109

Table 4: Design matrix and responses for the central composite design experiments.

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