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| Figure 1: Parkin substrates related to EGF-R and PLC signaling. Parkin prevents the endocytosis of the EGF-R by mono-ubiquitinating Eps15. PLCĪ³1 is activated by binding to the EGF-R and parkin ubiquitinates and regulates the degradation of PLCĪ³1. Pael-R is activating PLC and its degradation is regulated by parkin ubiquitylation. |
