| Figure 1: Model for involvement of CIN85 in internalization of D2DR. CIN85
localizes to the postsynaptic compartment of striatal neurons where it coclusters
with D2DRs. CIN85 interacts with endocytic regulators such as
dynamin, β-arrestin, and endophilins in the striatum (left panel). The absence
of striatal CIN85 causes insufficient complex formation of endophilins with
D2DRs in the striatum and ultimately attenuates D2DR endocytosis in
striatal neurons in response to dopamine stimulation. The defect of D2DR
endocytosis induces hyperactivity (right panel) [18]. |
D2DR: D2 dopamine receptor; PSD-95: postsynaptic density protein-95.