Study N Timepoint OC (ng/mL) BAP (U/L) CTX (ng/mL)
[8] 24 Baseline 5.4 ± 0.8† NA 0.699 ± 0.027
    Weight Loss 6.7 ± 0.9*† NA 0.919 ± 0.036*
[15] 17 Baseline 6.6 ± 1.0† 13.3 ± 2.0† 0.288 ± 0.032
    Weight Loss 8.3 ± 1.0*† 12.6 ± 2.0† 0.327 ± 0.039*
[8] 36 Baseline 11.4 ± 0.9† 17.4 ± 0.7† 0.607 ± 0.044
    Weight Loss 12.5 ± 1.0* 17.6 ± 0.7† 0.700 ± 0.057*
[14] 46 Lean, active controls 14.4 ± 0.6 24.2 ± 1.2 NA
Data are means ± SEM. NA, not assessed. BMI, body mass index; OC, osteocalcin; BAP, bone-specific alkaline phosphatase; CTX, C-terminal peptide of type I collagen*, significantly different from Baseline mean within each study; †, significantly different from lean, active controls, P<0.05
Table 3: Serum markers of bone formation and resorption in sedentary, overweight or obese women before and after weight loss compared with active, lean controls
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