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| Figure 1: Effects of MetS on insulin signaling in the kidney. In the glomerulus insulin resistance induced by and/or concomitant with MetS leads to the impairment of insulin signaling in the glomerulus. This leads to diabetic nephropathy probably due to podocyte injury. In contrast in the proximal tubule insulin signaling is preserved, and hyperinsulinemia triggers increment of proximal reabsorption and hypertension. |
