Week -6 (n=14) Week 0 (n=14) Week 6 (n=14) Week 12 (n=14)
Age (yrs) 68.9±0.7 68.9±0.7 68.9±0.7 68.9±0.7
Body Mass (kg) 76.5±3.7 75.9±3.8 76.2±3.9 76.4±3.8
BMI (kg·m-2) 30.2±1.4 30.0±1.4 30.1±1.4 30.1±1.4
Waist/Hip Ratio 0.86±0.02 0.85±0.02 0.86±0.02 0.86±0.02
Blood Pressure (mmHg)        
SBPrest 134±3 133±2 130±3 122±3*
DBPrest 76±2 75±2 70±2 69±2*
Blood Profile        
ADMA (mmol·L-1) 0.68±0.04 0.71±0.02 0.69±0.04 0.62±0.03*
Homocysteine (mmol·L-1) 12.8±1.8 11.6±1.3 11.6±0.9 11.6±0.8
Glucose (mmol·L-1) 7.4±0.5 7.5±0.5 7.0±0.4 7.2±0.4
HbA1C (%) 6.6±0.2 6.6±0.2 6.5±0.2 6.7±0.2
HbA1C (mmol·mol-1) 49±2 49±2 48±2 50±2
Insulin (mU·L-1) 11.3±2.3 11.0±2.2 12.9±2.6 13.6±3.5
Exercise Responses        
TE (min) 13.7±0.5 13.9±0.4 15.4±0.4* 16.4±0.4*
VO2peak (L·min-1) 1.49±0.03 1.45±0.04 1.53±0.05 1.59±0.05*
VO2peak (mL·kg-1·min-1) 20.0±0.9 19.6±1.1 20.5±0.9 21.4±1.0*
Peak HR (b·min-1) 143±3 141±5 144±4 145±3
VE peak (L·min-1) 51.7±1.8 50.8±2.4 55.2±2.4* 54.2±2.5
VO2Tge (L·min-1) 1.04±0.03 1.01±0.04 1.04±0.04 1.12±0.05*
Peak RER 1.10±0.02 1.11±0.03 1.13±0.03 1.07±0.02
BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; HbA1c, glycated hemoglobin; TE, time to exhaustion; VO2peak, peak oxygen uptake; HR, heart rate; VE, ventilation; VO2 Tge, oxygen uptake at gas-exchange threshold; RER, respiratory exchange ratio.
*p < 0.05, significantly different to pre-training (0 wk)
Table 1: Clinical characteristics of participating participants before (week -6) and after (week 0) 6 week intervention-free control period and after 6 and 12 weeks of exercise training (Mean ± SEM).
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