Treatment

     Na+

    K+

   HCO3-

    Cl-

C  (2ml/kg)

247.8±11.21

33.9±2.89

22.5±4.33

53.2±5.98

A

234.0±18.08

26.7±4.54

54.4±6.61b,ad

42.4±7.32

G

123.6±3.90a,ad

35.8±1.45

19.6±2.12ad

32.5±6.20b

AG

227.0±10.02

34.4±2.75

30.2±2.06

54.4±5.50

223.0±30.98

26.6±2.70

70.4±6.17b

39.6±7.39

KAG

236.4±0.60

35.6±2.35 ac

34.2±2.15 ac

61.6±6.49 ac

D

124.8±5.08 a

34.0±2.52

9.0±1.73 a

49.6±3.82

DG

199.4±13.18ab

34.9±3.54

59.8±5.06ab

41.0±7.13

DGA

216.4±21.75

19.4±1.59

28.4±1.21

46.8±7.39

KDGA

237.0±9.32

31.9±1.94ab

28.4±1.21

60.4±3.76


Values are mean + SEM.
(n=5 per group).
bp<0.05 significantly different from the control. abp<0.05 significantly different from the diabetic group treated with glibenclamide and amlodipine , acp<0.05 significantly
different from the potassium adapted group and cp<0.05 significantly different from the normal group treated with amlodipine and glibenclamide.
C: Control (normal saline group)
A: Normal group treated with amlodipine
G : Normal group treated with glibenclamide
AG: Normal group treated with both amlodipine and glibenclamide
K: Potassium adapted group
KAG: Potassium adapted treated with both glibenclamide and amlodipine
D: Diabetic group
DG: Diabetic group treated with glibenclamide
DGA: Non-adapted diabetic group treated with both glibenclamide and amlodipine
KDAG: potassium adapted diabetic group treated with both amlodipine and glibenclamide
Table 3: Effects of potassium-adaptation on urine electrolytes of normal and streptozotocin- induced diabetic rats treated with glibenclamide (5 mg/kg) and amlodipine (5 mg/kg).
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