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| Figure 3: The effects of PQIP on the growth of orthotopically implanted GEO colon cancer cells. A: GEO cells were labeled with GFP and injected s.c. into athymic nude mice. Tumor xenografts were implanted and PQIP treatment was carried as described above. Photographs show representative examples of GFP imaging results of the explanted colon. B: Quantification of the fluorescent tumor area (mm3) of PQIP treated and sham treated animals.C: Western blot analysis of IGF1R, IRS1, Akt phosphorylation and total protein contents in orthotopic implanted tumor tissues (shown are representative examples) after oral treatment with PQIP for 21 days (75 mg/Kg/day) as described. |
