Renal function test of rats in acute toxicity study of MCELE.
| Dose |
Sodium
(mmol/L) |
Pottasium
(mmol/L) |
Chloride
(mmol/L) |
CO2 (mmol/L) |
Anion gap
(mmol/L) |
Urea
(mmol/L) |
Creatinine
(µmol/L) |
| Vehicle
(CMC 0.5%) |
138.03 ± 0.44 |
4.96 ± 0.14 |
102.54 ± 0.15 |
22.03 ± 0.81 |
17.66 ± 0.72 |
5.03 ± 0.41 |
49.08 ± 0.85 |
| LD (2 g/kg) |
137.85 ± 0.43 |
5.00 ± 0.15 |
102.63 ± 1.22 |
21.87 ± 0.19 |
17.51 ± 0.68 |
4.98 ± 0.40 |
48.97 ± 0.83 |
| HD(5 g/kg) |
137.72 ± 0.41 |
4.89 ± 0.14 |
102.68 ± 0.76 |
22.13 ± 0.83 |
17.72 ± 0.75 |
5.19 ± 0.43 |
48.86 ± 0.61 |
Values expressed as mean ± S.E.M. There are no significant differences between groups. Significant value at p<0.05 |
Liver function test of rats in acute toxicity study of MCELE.
| Dose |
Total protein (g/L) |
Albumin (g/L) |
Globulin (g/L) |
TB (µmol/L) |
CB
(µmol/L) |
AP
(IU/L) |
ALT
(IU/L) |
AST
(IU/L) |
GGT
(IU/L) |
| Vehicle
(CMC 0.5%) |
71.57 ± 0.64 |
11.48 ± 0.43 |
59.97 ± 0.33 |
1.91 ± 0.16 |
0.95 ± 0.17 |
133.27 ± 6.17 |
51.79 ± 2.25 |
153.95 ± 2.36 |
5.13 ± 0.93 |
| 5.13 ± 0.93 |
71.49 ± 0.52 |
11.63 ± 0.35 |
59.81 ± 0.35 |
1.96 ± 0.14 |
1.00 ± 0.00 |
133.37 ± 7.03 |
51.90 ± 1.33 |
154.07 ± 3.51 |
5.09 ± 0.83 |
| HD
(5 g/kg) |
71.72 ± 0.63 |
11.61 ± 0.18 |
60.02 ± 0.61 |
1.88 ± 0.32 |
1.00 ± 0.00 |
133.15 ± 6.55 |
52.04 ± 2.27 |
153.88 ± 3.33 |
5.21 ± 0.91 |
Values expressed as mean ± S.E.M. There are no significant differences between groups. Significant value at p<0.05
TB: Total bilirubin; CB: Conjugated bilirubin; AP: Alkaline phosphatase; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase;GGT: G-Glutamyl Transferase. |
| Table 2: Acute toxicity test. |
