Case Age Sex Circumstances of death Cause of death at the end of the autopsy Brain lesions related to the death mechanism Associated brain lesions 1 41 M Interpersonal violence in a context of chronic alcohol and cannabis intoxication Bilateral pneumopathy complicating a sub-dural hematoma Uncal herniation with subdural hydroma + important and diffuse axonal ruptures in the white matter + diffuse vascular congestion Old lacunar infarct 2 41 M Suicide at home with massive drug and alcohol intoxication Asphyxia following Mendelsohn syndrome after massive drug and alcohol intoxication Diffuse vascular congestion Old traumatic lesions (temporal and frontal) 3 45 M Found dead on the ground in winter in a context of HIV+ and depression Hypothermia Slight diffuse vascular congestion and ischaemic neuronal lesions VIH encephalitis 4 56 F Found dead in the water of her bath-tub in a context of progressive dementia and muscle weakness Sudden death following arrhythmogenic right ventricular cardiomyopathy - Old and recent demyelinizing plaques 5 61 M Found dead at his table in a context of chronic alcohol intoxication Asphyxia following Mendelsohn syndrome after acute heart arrhythmia on ancient myocardial infarction Severe diffuse vascular congestion and ischaemic neuronal lesions Encephalopathy related to liver insufficiency and PP vitamin deprive + deterged old traumatic lesions 6 61 F Found at home, seated, in a context of chronic alcohol intoxication and familial violence Asphyxia following Mendelsohn syndrome after massive alcohol intoxication + old lesions of cerebral and cerebellum + pyometritis Intense diffuse vascular congestion Old traumatic lesions (temporal and frontal) 7 65 M Fire in his apartment in a context of chronic tobacco intoxication Acute CO intoxication - Deterged old traumatic lesions + senile degenerative alterations + atrophy of mammillary bodies possibly of alcoholic origin 8 67 M Traffic accident, death after one month of hospitalization Pulmonary embolism following prolonged confinement Cranio-cerebral trauma (left hemisphere lesion with sub-arachnoidal hemorrhage) Old traumatic lesion (right side) + Alzheimer type II glia + diffuse vascular lesions 9 71 M Found dead at home in a context of Parkinson disease, diabetes mellitus, kidney insufficiency, hypertension, and chronic alcohol intoxication No evident cause of death + diffuse atheromatosis lesions (including coronary arteries) - Senile neurofibrillar degenerescence 10 73 M Sudden collapse when going to the toilets in a context of chronic lymphoid leukemia Intra-cranial hemorrhage + left ventricular hypertrophic cardiomyopathy + old myocardial infarction + right ventricular dilated cardiomyopathy Extensive cerebral contusions + sub-arachnoidal hemorrhage + left temporal horn inundation + brain oedema + intracranial hypertension + uncal herniation Lesions related to chronic lymphoid leukemia 11 74 F Found dead at home in a context of Alzheimer disease and heart surgery Acute myocardial infarction - Degenerative and diffuse vascular lesions related to senile dementia 12 77 F Murder by chlorhydric acid absorption followed by strangulation attempt and knife wounds Diffuse physical burns on upper respiratory and digestive tracts Ischemic lesions related to agony Hypertensive arteriopathy lesions + moderate senile degenerative lesions 13 79 F Found dead at home in a context of diabetes mellitus, arterial hypertension, hyper-cholesterolemia, epilepsy, and slight dementia Acute myocardial infarction Vascular congestion Diffuse characteristic Alzheimer lesions + diffuse vascular alterations 14 84 F Suicide by precipitation in the Seine river in a context of Alzheimer disease Drowning - Characteristic diffuse Alzheimer lesions + senile degenerative lesions 15 85 F Suicide by precipitation from a height in a context of depression Bone and visceral polytrauma - Degenerative alterations and vascular lesions related to senile dementia

Table 1: List of all forensic autopsies for which the conclusions have been modified and/or completed by the neuropathological examination of the whole brain (n=15).

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