Treatment

      Na+

    K+

   HCO3-

     Cl-

C  (2ml/kg)

139.0±2.08

4.8±0.15

26.2±1.16

104.3±1.50

142.8±2.15

5.0±0.24

21.2±1.86b, ad

102.4±1.17

G

142.0±1.14

4.5±0.18

26.8±0.74

105.4±1.32

AG

143.8±1.56

4.6±0.22

27.2±0.86

106.0±1.79

146.0±1.09 b

5.3±0.36

24.4±0.40

105.2±1.49

KAG

144.6±1.78

4.6±0.16

25.0±0.55

105.8±1.74

D

140.8±1.08

4.6±0.12

24.2±0.54ac

103.4±1.78

DG

145.6±2.11

5.0±0.28

25.4±1.63ac

103.4±1.78

DGA

142.0±1.38

4.8±0.07

24.2±0.50

105.6±1.57

KDGA

145.4±1.87

4.6±0.22

24.8±0.86

107.0±1.00


Values are mean + SEM.
(n=5 per group).
bp<0.05 significantly different from the control. abp<0.05 significantly different from the diabetic group treated with gilbenclamide and amlodipine , acp<0.05 significantly
different from the potassium adapted group and cp<0.05 significantly different from the normal group treated with amlodipine and glibenclamide.
C: Control (normal saline group)
A: Normal group treated with amlodipine
G : Normal group treated with glibenclamide
AG: Normal group treated with both amlodipine and glibenclamide
K: Potassium adapted group
KAG: Potassium adapted treated with both glibenclamide and amlodipine
D: Diabetic group
DG: Diabetic group treated with glibenclamide
DGA: Non-adapted diabetic group treated with both glibenclamide and amlodipine
KDAG: potassium adapted diabetic group treated with both amlodipine and glibenclamide
Table 2: Effects of potassium-adaptation on plasma electrolytes of normal and streptozotocin- induced diabetic rats treated with glibenclamide (5 mg/kg) and amlodipine (5 mg/kg).
Goto home»