ID Sex Treatment Type No. Days from implant Description
2 F Placebo* Pituitary adenoma 1 287 Euthanized due to weight loss, lethargy, hunched posture, lack of coordination. Tumour 10 x 8 x 8 mm dark red soft tumour within the cranial cavity compressing overlying brain.
14 F Placebo Fibro-adenoma 1 168 Found at post mortem. Well-demarcated, soft, pale fatty mass, subcutaneously caudal to the left thigh muscle.
18a. F Placebo Fibro-adenoma 1 287 Surgically removed. Positioned under left front leg.
18b. F Placebo Fibro-adenoma 3 462 3 tumours surgically removed.
23 F Control Fibro-adenoma 1 511 Surgically removed from left side of chest.
42a. M Control Fibro-adenoma 1 315 Surgically removed from right side of back, above its hind leg.
42b. M Control Islet adenoma 1 515 Found at post mortem. Seen in the pancreas.
18 F Placebo Fibro-sarcoma 1 562 Found at post mortem. A 25mm sarcoma in subcutis (seen histologically)
22a. F Placebo Fibro-sarcoma 2 562 Found at post mortem. Two 5 – 9 mm sarcomas in the subcutis (seen histologically)
22b. F Placebo Metastic sarcoma 1 562 Found at post mortem. Seen in the lymph node, in association with subcutaneous sarcoma.
42 M Control Fibro-sarcoma 1 515 Found at post mortem. 4mm x 6mm deep within the subcutis (seen histologically)
9 F Naltrexone Colon 1 477 Lymphoma
27 F Naltrexone Colon 1 168 Mural lymphosarcoma
51a. M Naltrexone Liver 1 350 Lymphosarcoma with portal infiltrates of lymphocytes. Centrilobular hydropic degeneration and necrosis.
51b. M Naltrexone Spleen 1 350 Lymphosarcoma with loss of lymphoid nodules and expansions of the Periarteriolar Lymphoid Sheath (PALS).
* The implant was ejected at day 78 post implant and re-implanted with a placebo implant at day 170.
Table 2: The three types of tumours, adenoma, sarcoma and lymphomas observed in rats represent three basic types of tissue in the body; epithelial, mesenchymal and round cell tissue.
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