Rat No. Sex Treatment Location Days from implant Description 3 F Control Adrenal 363 Medulla hyperplasia of the adrenal 9a F Naltrexone Pituitary 477 Nodular hyperplasia in the pars distalis 9b F Naltrexone Adrenal 477 Medulla hyperplasia of the adrenal 10 F Control Adrenal 363 Focal nodular hyperplasia in the cortex of the adrenal 18 F Placebo Thyroid 563 Unilateral nodular hyperplasia in the thyroid 23 F Control Pituitary 563 Nodular hyperplasia in the pars distalis 31 M Control Pituitary 479 Nodular hyperplasia in the pars distalis 42 M Control Pituitary 517 Nodular hyperplasia in the pars distalis 44 M Placebo Pituitary 517 Nodular hyperplasia in the pars distalis 49 M Control Adrenal 477 Medulla hyperplasia of the adrenal

Table 3: Hyperplasia was noted in the adrenal, pituitary and thyroid in animals in each of the groups in this study.

Goto home»