| S.No. |
Parameters |
Group I |
Group II |
Group III |
Group IV |
| 1 |
GSH (µmole/gm tissue) |
4.12±0.21 |
1.65± 0.14*** |
2.08± 0.28* |
3.21± 0.35*** |
| 2 |
Protein (mg/gm tissue) |
5.57 ±0.28 |
8.62± 0.40*** |
7.79± 0.34*** |
6.18±0.16*** |
| 3 |
Albumin (mg/gm tissue ) |
3.69 ± 0.30 |
6.94 ±0.40*** |
6.17± 0.23** |
4.58±0.48*** |
| 4 |
LDH activity (IU/L) |
1593.87± 51.51 |
2998.48 ± 305.31*** |
2278.34 ±713.12** |
1979.83± 32.0*** |
| 5 |
Nitric oxide (µmole/gm tissue) |
1.73 ± 0.12 |
3.41 ± 0.19*** |
2.87± 0.24*** |
2.01± 0.14*** |
| 6 |
MDA (µmole/gm tissue) |
2.51± 0.861 |
6.10 ± 1.23*** |
5.44 ± 1.09ns |
3.67± 0.59*** |
| 7 |
TNF-α (pg/ml ) |
315.21± 25.16 |
1189.2 ± 82.14*** |
897.56± 66.87*** |
579.36± 61.44*** |
| 8 |
IL-6 (pg/ml ) |
463.78 ± 51.64 |
1477.31± 110.11*** |
1199.9± 94.56*** |
687.54± 36.56*** |
All results were mean ± SD of eight animals. Where Group I is control; group II
is pneumonia induced; group III is ceftriaxone treated and group IV is CSE1034
treated . Tukey’s post test was analyzed statistical significant between control
group vs infected group and infected group vs drug treated group. Where *** is
highly significant (p<0.001), ** is significant (p<0.01), * is significant (p<0.05) Ns;
not significant (p>0.05) |
