Drug (Aptamer) ClinicalTrials.gov Identifier: Phase Condition Sponsor
ARC1905 NCT00950638 Phase I
Active, not recruiting
Age-Related Macular Degeneration Ophthotech Corporation
E10030 NCT01089517 Phase II
Active, not recruiting
Age-Related Macular Degeneration Ophthotech Corporation
E10030 NCT00569140 Phase I
Completed
Age-Related Macular Degeneration Ophthotech Corporation
ARC1905 NCT00709527 Phase I
Completed
Age-Related Macular Degeneration Ophthotech Corporation
EYE001 anti-VEGF aptamer NCT00021736 Phase II
Phase III
completed
Macular Degeneration
Choroidal Neovascularization
Eyetech Pharmaceuticals
REG1 NCT00113997 Phase I
completed
Healthy, improve control of "blood thinning" National Heart and Lung, and Blood Institute
(NHLBI)
EYE001 NCT00056199 Phase I
completed
Hippel-Lindau Disease National Eye Institute (NEI)
pegaptanib sodium (Macugen) NCT00215670 Phase II
Phase III, completed
Age-Related Macular Degeneration Eyetech Pharmaceuticals , Pfizer
Pegaptanib sodium NCT00312351 Phase IV, terminated Macular Degeneration Eyetech Pharmaceuticals , Pfizer
Pegaptanib sodium NCT00321997 Phase II
Phase III, completed
Age-Related Macular Degeneration Eyetech Pharmaceuticals , Pfizer
pegaptanib sodium (Macugen) NCT00040313 Phase II, completed Diabetic Macular Edema Eyetech Pharmaceuticals , Pfizer
AS1411 NCT01034410 Phase II, terminated Acute Myeloid Leukemia Antisoma Research
NOX-E36 NCT00976729 Phase I, completed Chronic Inflammatory Diseases
Type 2 Diabetes Mellitus
Systemic Lupus Erythematosus
Noxxon Pharma AG
NOX-A12 NCT01194934 Phase I, completed Hematopoietic Stem Cell Transplantation Noxxon Pharma AG
NOX-A12 NCT00976378 Phase I, completed Autologous Stem Cell Transplantation Noxxon Pharma AG
ARC1779 NCT00694785 Phase II, has been withdrawn prior to enrollment Von Willebrand Disease Archemix Corp.
ARC1779 NCT00632242 Phase II, completed Purpura, Thrombotic Thrombocytopenic
Von Willebrand Disease Type-2b
Archemix Corp.
ARC19499 NCT01191372 Phase I
Phase II , no started
Hemophilia Archemix Corp.
Macugen (Pegaptanib Sodium) NCT01487044   Diabetic Macular Edema Retina Institute of Hawaii

Drug: Macugen (Pegaptanib Sodium)
NCT01487070 Phase I, completed PDR Retina Institute of Hawaii
Table 1: Aptamers in clinical trials (www.ClinicalTrials.gov).
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