| Parametersa |
Control (n=8) Mean ± SD |
rhGH 0.1 mg/kg (n=6) Mean ± SD |
rhGH 2 mg/kg (n=8)
Mean ± SD |
| T1/2 (hr) |
1.86 ± 0.32 |
1.30 ± 0.22b |
1.72 ± 0.10c |
| MRT (hr) |
2.03 ± 0.33 |
1.70 ± 0.43 |
1.97 ± 0.26 |
| AUCt (µg*hr/mL) |
35.1 ± 4.6 |
38.2 ± 6.9 |
49.5 ± 8.2bc |
| AUC¥ (µg*hr/mL) |
37.3 ± 5.5 |
39.3 ± 6.8 |
51.4 ± 8.4bc |
| Varea (L/kg) |
1.80 ± 0.17 |
1.21 ± 0.21b |
1.23 ± 0.22b |
| Vss (L/kg) |
1.37 ± 0.19 |
1.10 ± 0.29 |
0.990 ± 0.249b |
| CL (L/hr/kg) |
0.685 ± 0.109 |
0.654 ± 0.119 |
0.497 ± 0.076bc |
| CLr (L/hr/kg) |
0.0175 ± 0.0037 |
0.0136 ± 0.0050 |
0.0135 ± 0.0091b |
| CLm (L/hr/kg) |
0.667 ± 0.105 |
0.643 ± 0.171 |
0.484 ± 0.075b |
| fe |
0.0254 ± 0.0026 |
0.0206 ± 0.0048 |
0.0274 ± 0.0040 |
a T1/2 = half-life; MRT = mean residence time; AUCt = area under the plasma curve
to the last concentration; AUC¥ = area under the plasma curve to the infinity; Varea
= apparent volume of distribution; Vss = apparent volume of distribution at steady
state; CL = total body clearance; CLr = renal clearance; CLm = metabolic clearance; fe = fraction excreted unchanged
b Significantly different from control group, p<0.05
c Significantly different from the rhGH 0.1 mg/kg/day group, p<0.05 |
