DTIC
IFN
1.6 mg Ta1
(N=97)
DTIC
IFN
3.2 mg Ta1
(N=97)
DTIC
IFN
6.4 mg Ta1
(N=98)
DTIC
Ta1
(3.2 mg)
(N=99)
Combined Total
Ta1
(N=391)
DTIC
IFN
(Control)
(N=95)
Median overall survival (months)
9.3
8.6
10.3
9.3
9.4
6.6
Progression-free survival 6 months (%)
12
21
13
16
16
9
Overall tumor response number (%)
7
(7.2%)
10
(10.3%)
6
(6.1%)
12
(12.1%)
35
(9.0%)
4
(4.1%)
Abbreviations: DTIC = dacarbazine; IFN = interferon; N = number; Ta1 = thymosin alpha 1
Table 3:
Ta1 improves OS, PFS, and tumor response in stage IV melanoma.
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