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| Figure 3: Comparison between normal, glioblastoma, gamma secreatase inhibition and two proposed drug target scenarios. NNS: Normal Notch Pathway; GBS: Glioblastoma Scenario; GSI: Gamma Secreatase Inhibition; TS1: NICD1 and HIF1A combinatorial inhibition; TS2: NICD1 and MAML combinatorial inhibition. (A) Represents number of upstream activator molecules (Y-axis) activating the molecules (X-axis) representing significant variations (B) Represents number of downstream activated molecules (Y-axis) activated by the molecules (X-axis) representing significant variations (C) Represents number of upstream inhibitor molecules (Y-axis) inhibiting the molecules (X-axis) representing significant variations (D) Represents number of downstream inhibited molecules (Y-axis) inhibited by the molecules (X-axis) representing significant variations. |
