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| Figure 7: Activation and Inactivation of Heterotrimeric G-Proteins through GPCRs. Prior to agonist binding, the Gαβγ complexes are associated with each other. GDP is bound to the Gα subunit rendering it inactive. Upon agonist binding, the Gα subunit dissociates from the Gβγ complex and GTP binds the Gα subunit, initiating signalling events. After signal transduction, GTP is hydrolyzed back to GDP by Gα-GTPase and the Gα subunit associates with the Gβγ complex. |
