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| Figure 12: Structure of Common N-glycans. N-linked glycosylation at the ER involves the addition of oligosaccharides to asparagine residues within a sequence of asparagine-X-serine/ threonine. (A) Terminal glucose residues are cleaved by glucosidases and oligomannoses are generated. During trafficking of glycoproteins from the ER to the Golgi, glycans can be extensively modified to form either (B) hybrid or (C) complex N-glycans. The cleavage sites of glycosidase enzymes PNGase F and Endo H are indicated. Asn= Asparagine; Fuc= Fructose; Gal= Galactose; GlcNAc= N-acetylglucosamine; Man= Mannose; Ser= Serine; Thr= Threonine; X= any amino acid except proline. |
