| Compound |
Conc. (logM) |
1 Day |
2 Days |
7 Days |
| Apoptosis (mean%, n=2) |
Necrosis (mean%, n=2) |
Viable cells (%) |
Apoptosis (mean%, n=2) |
Necrosis (mean%, n=2) |
Viable Cells (%) |
Apoptosis (mean%, n=2) |
Necrosis (mean%, n=2) |
Viable Cells (%) |
| RFUdR |
-5 |
0.7 (1.2)* |
0.7 (0.4) |
98.6 |
36.7 (0.1) |
9.7 (0.1) |
53.6 |
94.8 (1.0) |
0 (0.1) |
5.2 |
| -6 |
0.9 (0.8) |
1.7 (3.3) |
97.4 |
12.6 (1.5) |
9.7 (1.4) |
77.7 |
62.8 (29.0) |
10 (9.7) |
27.2 |
| BTCEP-BFUdR |
-5 |
0.1 (0.8) |
0.2 (1.1) |
99.7 |
21.6 (3.3) |
16.3 (1.6) |
62.1 |
84.8 (4.0) |
2.5 (3.4) |
12.7 |
| -6 |
0.3 (0.2) |
0 (0.2) |
99.7 |
0.3 (0.2) |
0.2 (0.7) |
99.5 |
1.5 (1.6) |
1.5 (0.4) |
97 |
| FUdR |
-5 |
0.6 (1.7) |
0.5 (0.7) |
98.9 |
27.5 (2.2) |
19.8 (0.2) |
52.7 |
83.9 (5.5) |
6.9 (8.2) |
9.2 |
| -6 |
0.5 (0.3) |
1.8 (0.7) |
97.7 |
19.9 (2.5) |
17.8 (1.7) |
62.3 |
38.7 (25.8) |
8.9 (2.1) |
52.4 |
| RA |
-5 |
0.0 (0.2) |
0.0 (0.4) |
100 |
0.5 (0.7) |
0.0 (0.3) |
99.5 |
56.9 (2.8) |
5 (2.5) |
38.1 |
| -6 |
$ |
$ |
$ |
$ |
$ |
$ |
23.0 (0.4) |
4.7 (3.1) |
58.9 |
| NaBu |
-3 |
0.3 (1.0) |
0.0 (0.1) |
99.7 |
0.5 (0.5) |
0.0 (0.6) |
99.5 |
1.5 (0.9) |
1.2 (1.2) |
97.3 |
*Data have been normalized with reference to the respective control (drug-untreated) data.
#Data in parentheses represents the differences between duplicate experiments.
$No discernible change.
|
