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| Figure 1: Bilateral perspectives into the entity of cancer stem cells (CSCs). CSCs are defined to show the self-renewal and multi-lineage differentiation potential, which contribute to the formation of the heterogeneous cellular population in the tumor tissue. On the other hand, CSCs have the biological characteristics to maintain the “stemness”; resistance to ROS or DNA damage, adaptation to hypo-nutrient or growth factor microenvironment and metabolic reprogramming. It still remains elusive, however, these two cell populations are exactly the same entity each other. |
