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| Figure 2:Redox stress-induced Wnt activation and EMT. ROS stimuli-induced Wnt activation, TGF-β signaling, and EMT-inducing transcriptional factors such as Snail, Slug, Twist etc. enhance the invasive and migratory phenotype with the cadherin switch and the change in the alternative splicing of CD44. The splicing of CD44 mRNA is regulated by ESRP1, the expression of which is influenced by epigenetic changes. |
