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| Figure 4: A: Normal saline treated rat group showing normal histological picture without any signs of inflammation or bone damage. B and C: Non-treated arthritic rat group showing severe infiltration of inflammatory cells and cartilage and bone erosion ( midlle and right arrows), synovial hyperplasia, pannus formation (right arrow of Figure C). D: Arthritic-resveratrol-leflunomide treated rat group showing significant less infiltration of inflammatory cells ( left arrow) and absence of synovial hyperplasia and pannus formation ( right arrow) and normal picture cartilage and bone (middle arrow). E: Arthritic-resveratrol treated rat group showing very mild infiltration of inflammatory cells (right arrow) and absence of synovial hyperplasia and pannus formation (middle arrow) and very mild damage to cartilage and bone of joints (left arrow). F: Arthritic-leflunomide treated rat group showing also a very mild degree infiltration of inflammatory cells (right arrow) and absence of synovial hyperplasia and pannus formation (middle arrow) and a very mild degree of damage of joint’s cartilage and bone (left arrow). |
