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| Figure 2: Histological study of the absolute ethanol-induced gastric mucosal damage in rats. 2a rats pre-treated with 5 ml/kg of CMC (ulcer control). There is moderate to severe disruption to the surface epitheliumand necrotic lesions penetrate deeply into mucosa (arrow) and extensive edema of submucosa layer and leucocyte infiltration are present (arrow). 2b rats pre-treated with omeprazole (20 mg/kg). Mild disruption of the surface epithelium mucosa are present but deep mucosal damage is absent. 2c rat pre-treated with MCELE (250 mg/kg). Mild disruption of surface epithelium are present but deep mucosal damage is absent. There is edema and leucocytes infiltration of the submucosal layer. 2d rats pre-treated with MCELE (500 mg/kg). There is mild disruption to the surface epithelium with no edema and no leucocyte infiltration of submucosal layer (H & E stain 20x). |
