Strategy 1 Strategy 2 Strategy 3 Reaction step Score Reaction step Score Score Reaction step Score Score GLT 1.00 G6PDH 1.00 GLT 1.00 G6PDH 0.46 GLT 0.60 G6PDH 0.46 Phi exc. 0.39 AK 0.48 RibPiso 0.36 GPI 0.36 TrKet1 0.41 GPI 0.35 RibPiso 0.36 GAPDH 0.37 TPI 0.34 Comp. II+III+IV 0.35 GSSGRD 0.36 Phiexch 0.34 TPI 0.34 RibPepi 0.36 PGLDH 0.34 ALD 0.34 TrKet2 0.35 PPRPPS 0.33 PGLDH 0.34 TrAld 0.35     PRPPS 0.33 PGK 0.35     Phi trs. 0.24 BPGP 0.32

Table 2: Suitability of the enzymes as drug target when only metabolite concentrations are sampled. The suitability of each enzyme as drug target is assessed with regard to the three clinical strategies described in the text. The score associated to each enzyme is computed through Equation (16) with weight factors wσ=4, wτ=2 and wρ=1. Only enzymes with positive average selectivity are shown.

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