Strategy 1 Strategy 2 Strategy 3
Reaction step Score Reaction step Score Score Reaction step Score Score
GLT 1.00 G6PDH 1.00 GLT 1.00
Phi exc. 0.49 GLT 0.59 Phiexch 0.42
GPI 0.42 AK 0.48 GPI 0.41
ACO 0.38 TrKet1 0.40 G6PDH 0.34
G6PDH 0.35 GSSGRD 0.37 RibPiso 0.34
Phi trs. 0.35 GAPDH 0.36 TrAld 0.34
RibPiso 0.34 RibPepi 0.35 TrKet2 0.34
TPI 0.34 TrKet2 0.35 TrKet1 0.32
TrAld 0.34 TrAld 0.35    
TrKet2 0.34 PGK 0.35    
Table 3: Suitability of the enzymes as drug targets when both metabolite concentrations and kinetic parameters are sampled.
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