Broad group Description AML with certain recurrent genetic abnormalities AML with a translocation between chromosomes 8 and 21 AML with a translocation or inversion in chromosome 16 AML with changes in chromosome 9 and 11 APL (M3), with translocation between chromosomes 15 and 17 AML with multilineage dysplasia More than one abnormal myeloid cell type is involved AML related to a previous chemotherapy or radiation   AML not otherwise specified (includes cases of AML not in the previous broad groups) M0: Undiferentiated AML M1: AML with minimal maturation M2: AML with maturation M4: Acute myelomonocytic leukemia M5: Acute monocytic leukemia M6: Acute erythroid leukemia M7: Acute megakaryoblastic leukemia Acute basophilic leukemia Acute panmyelosis with fibrosis Myeloid sarcoma (also known as granulocytic sarcoma or chloroma)

Table 2: World Health Organization (WHO) classification of AML Although FAB classification is still in use, it does not take into account many of the clinical factors that impact diagnosis (outlook). In 2001, the World Health Organization (WHO) published a new system to better classify cases of AML based on patient’s outlook.

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