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| Figure 2: Simulation of wild type fission yeast S. pombe cell cycle regulation. The dynamics profiles of sequentially activated and inactivated regulators are seen over a period of two cycles and the cell cycle time is about 150 minutes. All the regulatory protein concentrations are normalized with their respective maximum concentrations. (a) G1 and S phase regulators Cdc2-Puc1 (solid black), Cdc2-Cig2 (dash-dotted) and Rum1 (solid red); (b) Negative regulatory kinase Wee1(dash-dotted), Mik1(solid black) and the positive regulator Cdc25p (solid red); (c) PP1 (dash-dotted), preMPF (solid black) and MPF (solid red) ; (d) Mitotic exit and M-G1 transition regulators APCp-Slp1(dash-dotted), Separase (solid black), APCp-Ste9 (solid red), PP2 (solid blue) and Mass. |
