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| Figure 1: Genital development viewed in Bmp7-lacZ mouse model [29]. (A) Extending urethral plate (up) epithelium is marked by LacZ. (B) Lateral view of male urogenital system at E17.5, and genital sections (C, D). During sexual differentiation at E14.5-18.5 urethral cleft undergoes a progressive fusion starting from proximal (D) to distal (C) regions as the Bmp7-expressing mesenchyme (arrow in D) advances to the genital tip. Bl, bladder; ur, urethra; ck14, cytokeratin 14. |
