| |
Coffee use |
|
|
| |
|
Null |
|
Weekly |
|
Daily |
Trend |
Interaction |
| Genotype |
na |
ORb |
na |
OR (95% CI)b |
na |
OR (95%CI)b |
P |
P |
| Current smokers |
|
|
|
|
|
|
|
|
| CYP1A2*1C |
|
|
|
|
|
|
|
|
| GG |
12/23 |
1.00 (referent) |
11/63 |
0.28 (0.10-0.80) |
31/322 |
0.16 (0.06-0.39) |
<0.0001 |
0.03 |
| GA + AA |
3/30 |
1.00 (referent) |
9/41 |
2.27 (0.49-10.5) |
30/235 |
1.37 (0.35-5.38) |
0.92 |
|
| CYP1A2*1F |
|
|
|
|
|
|
|
|
| AA |
5/23 |
1.00 (referent) |
8/38 |
0.64 (0.15-2.75) |
30/241 |
0.39 (0.11-1.37) |
0.10 |
0.52 |
| CA+CC |
10/31 |
1.00 (referent) |
13/66 |
0.63 (0.23-1.72) |
31/316 |
0.33 (0.14-0.81) |
0.008 |
|
| Nonsmokers |
|
|
|
|
|
|
|
|
| CYP1A2*1C |
|
|
|
|
|
|
|
|
| GG |
13/65 |
1.00 (referent) |
10/108 |
0.44 (0.17-1.14) |
24/281 |
0.43 (0.19-0.96) |
0.07 |
0.59 |
| GA+AA |
9/63 |
1.00 (referent) |
9/87 |
1.04 (0.33-3.27) |
17/191 |
0.73 (0.26-2.04) |
0.48 |
|
| CYP1A2*1F |
|
|
|
|
|
|
|
|
| AA |
7/63 |
1.00 (referent) |
10/80 |
1.56 (0.43-5.72) |
11/209 |
0.38 (0.11-1.30) |
0.06 |
0.53 |
| CA+CC |
15/67 |
1.00 (referent) |
9/115 |
0.34 (0.13-0.87) |
30/263 |
0.51 (0.24-1.10) |
0.20 |
|
OR, odds ratio; CI, confidence interval.
aNumber of cases/controls.
bAdjusted for age, hospital, rank in the Self-Defense Forces, leisure-time physical activity, body mass index, current use of alcoholic beverages (sake, shochu, beer, whisky
and wine), past alcohol use and green tea intake. |
