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| Figure 1: PPARγ domain structure. PPARγ is a ligand-activated transcription factors belonging to the nuclear receptors family. Upon their activation by their ligands, PPARγ form heterodimers with the nuclear receptor RXR. The heterodimer binds to specific DNA-response elements in target genes known as PPRE. The PPARγ2 (γ2) protein contains an additional 30 amino acids at the N terminus compared to PPARγ1 (γ1). DNA-binding domain (DBD), ligand-binding domain (LBD), and activation function 1 & 2 (AF-1/2) are shown. |
