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| Figure 3: In obesity-linked type 2 diabetes, characterized by increased lipid and glucose circulating levels in the body, adipose tissue secretions profile actively contribute to the development of diabetic cardiomyopathy. In addition to the negative influence of glucose and lipid disturbed homeostasis on cardiac function, modulation of the adipose tissue activity, illustrated by an increase PPARĪ³ activity, by the hyperlipidemia and hyperglycaemia directly influence the cardiac physiology through its adipokine secretion profile modulation. |
