Substance Cell Chemerin Ref Substance CMKLR1 Ref IL-6 50 ng/ml PHH mRNA ↔ [21] IL-6 50 ng/ml mRNA ↑ [21] IL-6 5, 20 ng/ml PHH CP, SN ↔ [13] IL-6 5 ng/ml CP ↔ [14] IL-6 Hep3B mRNA ↔ [27]                     IL-1beta 10 ng/ml Hep3B mRNA ↔, SN ↓ [27]                     Glucagon 100 nM PHH mRNA ↔ [21] Glucagon 100 nM mRNA ↔ [21] Insulin 100 nM PHH mRNA ↔ [21] Insulin 100 nM mRNA ↔ [21] Palmitate 0.3 mM PHH mRNA ↔ [21] Palmitate 0.3 mM mRNA ↔ [21] Palmitate 0.3 mM PHH CP ↔, SN (↓) [12] Palmitate 0.3 mM mRNA, CP ↔ [14] Oleate 0.3 mM PHH CP, SN ↔ [12] Oleate 0.3 mM mRNA, CP ↔ [14] Palmitate 0.1, 0.2, 0.5 mM HepG2 mRNA, SN ↓ [26]       FXR agonist 1, 2, 5 µM HepG2 mRNA ↑ [26]       FXR agonist 1, 2, 5 µM PMH mRNA ↑ [26]       LXR agonist HepG2 mRNA ↔ [26]       PPARg agonist HepG2 mRNA ↔ [26]       PPARa agonist HepG2 mRNA ↔ [26]       Leptin 20 ng/ml PHH CP ↔, SN ↑ [13] Leptin 10, 20 ng/ml CP ↔ [14] TNFa 2 ng/ml PHH CP ↔, SN ↓ [13] TNFa 0.5, 2 ng/ml CP ↔ [14] TNFa 25 ng/ml Hep3B mRNA, SN ↔ [27]       TNFa 20 ng/ml PMH CP ↔ [12]       TGFβ5 ng/ml PHH CP ↔, SN ↑ [13] TGFβ 5 ng/ml CP (↓) [14] APN 10 µg/ml PHH CP ↔, SN ↓ [13] APN 10 µg/ml mRNA, CP ↑ [14] LPS10 µg/ml PHH CP, SN ↔ [13] LPS 1, 10 µg/ml CP ↔ [14]   PHH     ACAT Inh + AcLDL CP ↔ [14] Metformin 0.5, 1 mM PHH CP, SN ↓ [13]       Aspirin 2, 20 mg/l Hep3B mRNA, SN ↔ [27]

Acetylated LDL, AcLDL; adiponectin, APN; cellular protein, CP; farnesoid X receptor, FXR; liver X receptor, LXR; primary human hepatocytes, PHH; primary mouse hepatocytes, PMA; Inhibitor, Inh; peroxisome proliferator-activated receptor, PPAR; reference, Ref; supernatant, SN; not regulated, ↔; pregulated, ↑; downregulated, ↓; when arrows are given in brackets this indicates a trend.

Table 1: Regulation of chemerin and CMKLR1 in hepatocytes

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