rs4883263   rs7980201   Phenotypes Meansa p-valuesb Meansa p-valuesb   Common HMZ Rare allele carriers   Common HMZ Rare allele carriers   Number of subjects (N) 1764 106 --- 1513 335 --- BMI (kg/m2) 51.5 ± 8.5 51.2 ± 8.0 0.83 51.5 ± 8.6 51.1 ± 7.9 0.29 Waist girth (cm) 140.5 ± 17.6 139.2 ± 18.3 0.84 140.5 ± 17.8 139.9 ± 16.9 0.19 Fasting glucose (mM) 6.55 ± 2.34 6.63 ± 2.48 0.68 6.57 ± 2.37 6.51 ± 2.28 0.25 Lipid profile             Total-C (mM) 4.66 ± 0.95 4.81 ± 1.03 0.04 4.69 ± 0.97 4.57 ± 0.88 0.01 LDL-C (mM) 2.65 ± 0.83 2.71 ± 0.81 0.25 2.67 ± 0.85 2.60 ± 0.77 0.14 HDL-C (mM) 1.23 ± 0.36 1.24 ± 0.32 0.62 1.24 ± 0.35 1.24 ± 0.39 0.34 TG (mM) 1.81 ± 1.04 2.02 ± 1.46 0.01 1.82 ± 1.00 1.76 ± 0.96 0.23 Total-C / HDL-C 4.00 ± 1.28 4.12 ± 1.47 0.11 4.02 ± 1.27 3.93 ± 1.34 0.38 Blood pressure             SBP (mm Hg) 138.5 ± 16.8 137.1 ± 17.1 0.93 138.5 ± 17.1 137.5 ± 15.4 0.34 DBP (mm Hg) 83.3 ± 11.3 83.9 ± 9.8 0.66 83.4 ± 11.3 82.9 ± 10.6 0.32 CRP (mg/L) 10.81 ± 8.32 (N=1100) 9.90 ± 7.93 (N=68) 0.62 10.89 ± 8.57 (N=943) 10.44 ± 7.45 (N=209) 0.47

Boldface values represent statistically significant results (P ≤ 0.05). aValues presented (means ± SD) are untransformed and unadjusted values. bP-values obtained are adjusted for the effect of age, sex, BMI and medication use except for BMI and waist girth which were adjusted for age and sex. Abbreviations: N, number; Total-C, total cholesterol; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; TG, triglycerides; SBP, systolic blood pressure; DBP, diastolic blood pressure.

Table 4: Significant genotype differences identified in plasma fasting glucose and lipid levels and in blood pressure.

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