|
| Figure 1: Cyclic mechanical stretch suppresses MSC adipogenesis under BMP4 pre-treatment followed by adipogenic media exposure, and the suppression is potentially achieved via ERK signaling. (A) BMP4 signaling through Smad and p38 in MSCs was not affected by cyclic mechanical stretching. (B) ERK1/2 was significantly upregulated in MSCs by cyclic mechanical stretch relative to BMP4 treatment alone sample (##p<0.01 at the same time point).(C) The effect of cyclic stretch suppression of BMP4-mediated MSC adipogenesis was decreased when ERK is blocked by PD98059 (PD). Reprinted with permission from Elsevier [9] |
