| Study |
N |
Timepoint |
Glucose
(mg/dL) |
Insulin
(pmoL/L) |
HOMA2-IR |
HOMA2-%B |
HOMA2-%S |
| [8] |
24 |
Baseline |
100 ± 3† |
88 ± 9† |
1.68 ± 0.18† |
110 ± 11 |
80 ± 27† |
| |
|
Weight Loss |
92 ± 2*† |
NA |
NA |
NA |
NA |
| [15] |
17 |
Baseline |
93 ± 4† |
88 ± 11† |
1.65 ± 0.21† |
125 ± 13 |
79 ± 32† |
| |
|
Weight Loss |
81 ± 3* |
82 ± 13*† |
1.47 ± 0.20† |
158 ± 19* |
97 ± 30 |
| [8] |
36 |
Baseline |
97 ± 3† |
65 ± 9† |
1.28 ± 0.23† |
86 ± 11 |
143 ± 27† |
| |
|
Weight Loss |
87 ± 2*† |
61 ± 11*† |
1.11 ± 0.20† |
115 ± 17 |
192 ± 26* |
| [14] |
46 |
Lean, active controls |
82 ± 2 |
46 ± 7 |
0.84 ± 0.13 |
107 ± 8 |
201 ± 19 |
Data are means ± SEM. NA, not assessed. HOMA2-IR, -%B, and -%S homeostasis model assessment of insulin resistance, β-cell function, and insulin sensitivity
respectively. *,significantly different from Baseline mean within each study; †, significantly different from lean, active controls, P<0.05. |
| Table 2: Plasma glucose, insulin, and homeostasis model estimates of insulin resistance, ß-cell function, and insulin sensitivity in sedentary, overweight or obese women
before and after weight loss compared with active, lean controls. |
