Drug Classification Drugs Related gene polymorphisms rs number Genotype/Observation Ref
Sulfonylureas Sulfonylureas TCF7L2 G483+9017T rs12255372 GG/More sensitive to sulfonylurea [15]
 

Glibenclamide

KCNJ11 G635A rs5219 AA/Increased risk of secondary failure to sulfonylurea [13]
    CYP2C9*2   CYP2C9 *2/*3/Increased risk of severe hypoglycaemia [8]
    CYP2C9*3   CYP2C9 *3/*3/Increased risk of severe hypoglycaemia [8]
Meglitinides Repaglinide KCNJ11 G635A rs5219 GG/ Good drug efficacy [20]
    SLC30A8 C826T rs13266634 CC/ Poor drug efficacy. [21]
    SLC30A8 G827A rs168s89462 GG/ Poor drug efficacy [21]
    NAMPT G-3186T rs11977021 CT/ Poor drug efficacy [22]
    IGF2BP2 C239+29254G rs4402960 GG/ Good drug efficacy [23]
    IGF2BP2 A239+11861C rs1470579 AA/ Poor drug efficacy [23]
    TCF7L2 T948-1026C rs290487 TT/ Good drug efficacy [20]
    KCNQ1 C1795-10451T rs2237897 TT/ Good drug efficacy [44]
    CYP2C8*1   CYP2C8*1/*3/ Lower AUC(0-infinity) and Cmax of repaglinide [25]
    CYP3A4*1   CYP3A4*1/*18/Reduced mean elimination rate constant and increased mean half-life [26]
  Nateglinide CYP2C9*3   CYP2C9*3/*3 / Increased risk of hypoglycaemia. [27]
Metformin Metformin SRR T-4-2593C rs391300 GG/ Poor drug efficacy [58]
    SLC22A1 C181T
SLC22A1 G1201A
SLC22A1 G1393C
SLC22A1 M420del		 rs12208357
rs34130495
rs34059508		 Defective variants /Poor drug efficacy
Defective variants /Poor drug efficacy
Defective variants /Poor drug efficacy
Defective variants /Poor drug efficacy		 [50,51]
[50,51]
[50,51]
[50,51]
Table 1: Selected studies on pharmacogenomics of oral antidiabetic drugs.
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