Author

Number of patient

Age (year)

 

Site

Size (cm)

Ascites volume (ml)

Clinical presentation

CA 125 (U/mL)

Treatment

Prognosis and follow up

 

Amr and Hassan [14]

 

1

 

55

 

R

 

12 x 9 x 6

 

3,000

Abdominal distension, right  sided pleural effusion, ascites
 

 

-

TAH, BSO & partial omentectomy

 

Well, 36 months

 

Bethune et al. [15]

 

1

 

62

 

R

 

9 x 5 x 5

 

3,500

Abdominal swelling,  dyspnea, ascites & large bilateral pleural effusion

 

1621

 

TAH, BSO & infra-colic omentectomy

 

Well, 5 months

 

*Bokhari et al. [16]

 

1

 

51

 

R

 

15 x 6.5 x 11

 

-

Increasing abdominal girth, fatigue, dyspepsia, weight gain

 

1160

TAH, BSO & appendectomy
(frozen section performed)

 

-

 

Huh et al. [17]

 

1

 

   65

 

R

 

5 x 4 x 4

 

20,000

Abdominal distension,
Dyspnea, moderate bilateral effusion, marked ascites, pulmonary embolism

 

402

 

TAH, BSO, appendectomy and omental biopsy
(frozen section performed)

 

Well, 4 months

 

Hurlow et al. [18]

 

1

 

60

 

L

 

7.5 x 6.8 x 4.7

 

8,000

Chest pain, cough, mild dyspnoea, abdominal swelling, bilateral pleural pleural effusion, ascites

 

-

 

Laparotomy, BSO

 

-

 

*Jotkowitz et al. [19]

 

1

 

79

 

-

 

-

 

Several liters

Abdominal distension, epigastric pain & ascites

 

4670

TAH & BSO, omentecomy & peritoneal biopsies (frozen section performed**)

 

-

 

 

*Leung and Hammond [11]

 

 

2

 

60

 

77

 

R

 

L

 

10

 

8 x 10

 

500

 

4,000

Pelvic mass and small volume ascites

 

Pelvic mass & ascites,

 

224

 

 

2,860

TAH, BSO and omentectomy
(Frozen section perfomed)

TAH, BSO & left pelvic node sampling
(frozen section performed)

 

Well, 12 months

 

Well, 12 months

 

Loizzi et al. [20]

 

1

 

65

 

R

 

12 x 7

 

Few liters

Dyspnea,
diffuse abdominal pain, marked right sided pleural effusion, ascites

 

161

 

Laparotomy with RSO

 

Well, 2 months

 

*Loizzi et al. [3]

 

1

 

83

 

R

 

10 x 7 x 6.5

 

3,000

Abdominal distension, fatigue, anorexia, large amount of ascites

 

1570

 

TAH & BSO
(Frozen section perfmoed)

 

-

 

Long et al. [21]

 

 

2

 

 

53

 

78

 

 

L

 

L

 

 

15 x 11 x 7

 

12 x 10 x 5

 

 

4,100

 

-

 

Abdominal distension, weight loss, ascites, left pleural effusion

 

Abdominal distension, weight loss, ascites & bilateral pleural effusion

 

540

 

 

124

TAH, BSO, & infracolic omentectomy
(frozen section performed)

 

TAH &BSO
(frozen section performed)

Well, > 12 months

 

 

Well, 6 months

 

Mantouvalos et al. [22]

 

1

 

42

 

L

 

15

 

2,000

Abdominal pain and distension, dyspnea, cough, left sided pleural effusion, & ascites

 

-

 

TAH & BSO

 

-

 

*Mancuso et al. [23]

 

1

 

31

 

L

 

10 x 11 x 9

 

300

The pelvic mass was incidental finding. Ascites noted in the scan

 

689

Left salpingo-oophorectomy
(frozen section performed)

 

-

 

Mitrou et al. [24]

 

1

 

55

 

L

 

22 x 23 x 10

 

8,000

Large pelvic mass, ascites, small left sided pleural effusion

 

3803

TAH & BSO, infra-colic omentectomy & lymph nodes sampling

 

Well, 12 months

 

Obeidat and Amarin [25]

 

1

 

52

 

R

 

10 x 15 x 8

 

4,000

Dyspnea, marked ascites and moderate right sided pleural effusion

 

149

 

TAH, BSO and omentectomy

 

Well,
1 month

 

Paladini et al. [26]

 

1

 

42

 

R

 

11 x 7.3 x 8

 

8,000

Ascites, fever, diarrhea,
vomiting and significant
weight loss (hyperthyroidism).

 

2,548

 

RSO + ? TAH & LSO
(frozen section performed)

 

Well, 6 months

        

 

*Rim et al. [10]  

 

 

1

 

 

50

 

 

L

4 x 4 (struma ovarii)  attached to 3 x 3 mature cystis teratoma

 

 

3,000

 

 

Abdominal distention,  dyspepsia, massive ascites

 

 

878

 

 

TAH & BSO
(Frozen section performed)

 

 

Well, 10 months

 

Rana et al. [27]

 

1

 

70

 

R &  L

Bilateral benign struma; left: 7.5 x 5.5 x 4
Right: 2 x 1.5 x 1

 

-

Progressive abdominal distension, breathlessness, ascites, bilateral
pleural effusion

 

284

 

TAH, BSO & partial omentectomy

 

Well, >12 months

 

Jiang et al. [28]

 

1

 

46

 

R

 

20 x 18 x 15

 

6,000

Fatigue, anorexia, abdominal swelling, moderate ascities, marked pleural effusion
 

 

1230

 

TAH & BSO
(Frozen section performed)

 

Well, 3 months

 

Uehara and Sawada [29]

 

1

 

67

 

L

 

7 x 7

 

-

Qbdominal distension, dyspnea, massive ascites & bilateral pleural effusion

 

2086

 

TAH & BSO

 

-

 

 

*Mui et al. [12]

 

 

1

 

 

56

 

 

L

6 x 5 x 4 (struma ovarii)  coexist with 3 cm mature cystis teratoma

 

 

8,210

 

 

Abdominal distention, ascites 

 

 

5,218

 

TAH, BSO & omentectomy
(frozen section perfomed)

 

 

Well, > 4 months

 

*Guida et al. [30]

 

1

 

42

 

R

 

12 x 8.5 x 4

 

4,000

Fever, diarrhea, vomiting (hyperthyroidism), abdominal distension & lower limb edema

 

2,548

 

TAH & BSO

 

 

 

Morell et al. [8]

 

1

 

60

 

L

6 x 4 x 3
(2 cm teratoma found in the other ovary)

 

3,000

Abdominal pain & distension, left pleural effusion & ascites

 

-

 

TAH & BSO

 

-

 

*Lenehan et al. [13]

 

1

 

55

 

L

 

6 x 5 x 4

 

6,000

Epigastric pain, abdominal distension, change in bowel habits, & ascites

 

-

 

BSO
(previous TAH)

 

-

Present case

 

1

 

55

 

L

 

14 x 15

A total of 150,0000

Abdominal distension, ascites, left pleural effusion

 

872

Laparoscopic left Salpingo-oophorectomy

Well, 5 months

- i.e. not reported
*No pleural effusion prescribed
** Frozen section (DCG) was suggestive of adenocarcinoma, however, subsequent paraffin sections in the pathology department revealed benign a struma ovarii
Table 1: Benign struma ovarii associated with ascities + elevated CA125 level: reported cases.
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