Sensitivity %
(95 % CI)
Specifity %
(95 % CI)
PPV %
(95 % CI)
NPV %
(95 % CI)
Prevalence %
(95 % CI)
Notching,  1st trimester Pre-eclampsia 671 (30-93)
832(36-100)
403(05-85)
54 (37-69)
43 (22-66)
67 (41-87)
24 (09-45)
29 (10-56)
25 (03-65)
88 (69-97)
90 (55-100)
80 (52-96)
18 (09-31)
22 (09-42)
22 (07-44)
Notching, 2nd trimester Pre-eclampsia 35 (21-50)
40 (21-61)
35 (16-57)
76 (66-85)
78 (61-90)
71 (57-82)
43 (27-61)
56 (31-78)
33 (16-55)
69 (59-78)
65 (49-79)
72 (58-84)
34 (26-43)
41 (29-54)
29 (20-41)
PI  ≥ 2.5, 1st trimester Pre-eclampsia 22 (03-60)
33 (04-78)
00 (00-71)
88 (73-96)
81 (58-95)
95 (74-100)
29 (04-71)
33 (04-78)
00 (00-97)
83 (69-93)
81 (58-95)
86 (64-97)
18 (09-32)
22 (09-42)
14 (03-35)
PI  ≥ 2.5, 2nd trimester Pre-eclampsia 07 (01-18)
08 (01-27)
05 (00-23)
98 (92-100)
95 (82-99)
100 (93-100)
60 (15-95)
50 (07-93)
100 (03-100)
67 (58-75)
61 (48-74)
71 (59-81)
34 (26-43)
39 (27-53)
30 (20-42)
PI ≥ 2.5 + Notching, 1st trimester Pre-eclampsia 22 (03-60)
33 (04-78)
00 (00-71)
88 (73-96)
81 (58-95)
95 (74-100)
29 (04-71)
33 (04-78)
00 (00-97)
83 (69-93)
81 (58-95)
86 (64-97)
18 (09-32)
22 (09-42)
14 (03-35)
PI ≥ 2.5 + Notching, 2nd trimester Pre-eclampsia 04 (01-15)
04 (00-21)
05 (00-23)
99 (94-100)
97 (86-100)
100 (93-100)
67 (09-99)
50 (01-99)
100 (03-100)
66 (58-74)
61 (47-73)
71 (59-81)
34 (26-43)
39 (27-53)
30 (20-42)
Notching and/or PI ≥ 2.5,  1st trimester Pre-eclampsia 67 (30-93)
83 (36-100)
33 (01-91)
53 (36-86)
43 (22-66)
63 (38-84)
24 (09-45)
29 (10-56)
13 (00-53)
88 (68-97)
90 (55-100)
86 (57-98)
18 (09-32)
22 (09-42)
14 (03-35)
Notching and/or PI ≥ 2.5, 2nd trimester Pre-eclampsia 37 (23-52)
46 (26-76)
27 (11-50)
75 (65-84)
73 (56-86)
76 (63-87)
44 (28-60)
52 (30-74)
33 (13-59)
69 (59-79)
68 (51-81)
71 (57-82)
34 (26-43)
39 (27-53)
30 (20-42)
1Total population
2Group Prior PE
3Group C. H.
Table 1: Summary of predictive values.
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