Total duration of follow up (patient years) Hazard Ratio (95% CI) P Value
LPV/r 267 1.69 (1.1 to 2.60) 0.017
ATZ/r 562 1.52 (1.14 to 2.03) 0.004
DRV/r 451 1.31 (0.94 to 1.81) 0.108
EFV 1400 1  
¶ adjusted for Gender, Age at start of HAART, ethnicity, baseline eGFR, baseline CD4 count, baseline viral load, baseline Hepatitis C Antibody status, Hepatitis B Surface Antigen status and prior exposure to tenofovir/indinavir and total duration of tenofovir exposure

HAART highly active antiretroviral therapy NRTI nucleos(t)ide reverse transcriptase inhibitor ATZ atazanavir DRV darunavir LPV lopinavir EFV efavirenz r ritonavir eGFR estimated glomerular filtration rate
Table 4: Multivariate cox’s proportional hazards regression model showing likelihood of eGFR < 60 ml/min per 1.73m2 since starting HAART with 2NRTI+ATZ/r, 2NRTI+DRV/r, 2NRTI+LPV/r or 2NRTI+EFV. 
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