|   | 
  Total duration of follow up (patient years)  | 
  ¶ Hazard Ratio (95% CI)  | 
  P Value  | 
    
   
  | LPV/r  | 
  267  | 
  1.69 (1.1 to 2.60)  | 
  0.017  | 
    
   
  | ATZ/r  | 
  562  | 
  1.52 (1.14 to 2.03)  | 
  0.004  | 
    
   
  | DRV/r  | 
  451  | 
  1.31 (0.94 to 1.81)  | 
  0.108  | 
    
   
  | EFV  | 
  1400  | 
  1  | 
    | 
    
  
   ¶ adjusted for Gender, Age at start of HAART, ethnicity, baseline eGFR, baseline
 CD4 count, baseline viral load, baseline Hepatitis C Antibody status, Hepatitis B
 Surface Antigen status and prior exposure to tenofovir/indinavir and total duration
 of tenofovir exposure 
  
 HAART highly active antiretroviral therapy NRTI nucleos(t)ide reverse
 transcriptase inhibitor ATZ atazanavir DRV darunavir LPV lopinavir EFV efavirenz
 r ritonavir eGFR estimated glomerular filtration rate |